Cheick Tiote, Massadio Haidara and Daryl Murphy handed Newcastle starts
The two clubs take each other on at St Andrew's in a third-round FA Cup tie.
And Cheick Tiote, Daryl Murphy, Massadio Haidara and Grant Hanley have been handed rare starts by United manager Benitez.
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Hide AdMatz Sels, Achraf Lazaar, DeAndre Yedlin and Aleksandar Mitrovic also come into Benitez's side at St Andrew's, where Newcastle will be backed by more than 4,600 fans.
NEWCASTLE UNITED: Sels, Colback, Hanley, Lascelles, Lazaar, Anita, Haidara, Yedlin, Tiote, Murphy, Mitrovic. Subs: Darlow, Dummett, Clark, Hayden, Gouffran, Ritchie, Gayle.
BIRMINGHAM CITY: Legzdins; Spector, Shotton, Robinson, Grounds, Kieftenbeld, Gleeson, Davis, Fabbrini, Adams, Jutkiewicz.
For news and updates from St Andrew's, follow NUFC writer Miles Starforth on Twitter here