Millions of pounds will once again be raised to help tackle poverty, domestic abuse and racial inequality, as well as supporting front line workers.
It also gives us a chance to look back on the wonderful ways you have raised money in Sunderland and East Durham in the past.
Were you one of the Sunderland High School staff in fancy dress in 2011 or the Sainsbury’s staff at Silksworth who got a Comic Relief hair cut in 2013?
Maybe you were one of the Sunderland College students doing a sponsored fashion show in 1999.
We have all this and more for you to enjoy. Take a look and re-live the Red Nose memories.
1. Doing it in style
It's Red Nose Day in 2005 and these Parsons staff were having a great time. Remember this? Photo: TC
2. Bouncing back to 2013
A Comic Relief yoga session at the Phoenix Centre 8 years ago. Claire Modrate (Family Support Worker) (left) and Ivy-Rose Crowe look on as Sarah Noble and Isle Gabriella Jamieson, Sarah-Jayne Larking and Harrison Martin, Andrea and Lola Atkinson take part. Photo: FRANK REID
3. So colourful at Golden Flatts
Red Nose Day at Golden Flatts School in 2005. Do you recognise the pupils having fun? Photo: TC
4. Cleaning up in 2009
A sponsored car wash at Sainsbury's in Hartlepool in 2009. Did you take part? Photo: FLR